Toll-like Receptor 4 and Hepatic Fibrogenesis
نویسندگان
چکیده
منابع مشابه
Toll-like receptor 4 signaling in liver injury and hepatic fibrogenesis
Toll-like receptors (TLRs) are a family of transmembrane pattern recognition receptors (PRR) that play a key role in innate and adaptive immunity by recognizing structural components unique to bacteria, fungi and viruses. TLR4 is the most studied of the TLRs, and its primary exogenous ligand is lipopolysaccharide, a component of Gram-negative bacterial walls. In the absence of exogenous microbe...
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toll like receptors (tlrs) recognize pathogens and generate an immediate defense response by inducing the production of pro-inflammatory cytokines, which rapidly destroy or limit the pathogens. in their bridging role, tlr downstream signals link innate and adaptive immunity, particularly by mediating dc maturation and activation of pathogen specific t lymphocytes. these pathways lead to the act...
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ژورنال
عنوان ژورنال: Seminars in Liver Disease
سال: 2010
ISSN: 0272-8087,1098-8971
DOI: 10.1055/s-0030-1255353